Diffusion Properties and Models of Brain Interstitial Space
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References
C. Nicholson, S. Hrabĕtová, Brain extracellular space: The final frontier of neuroscience, Biophysical Journal, 113 (2017) 2133-2142. https://doi.org/10.1016/j.bpj.2017.06.052
C. Nicholson, The secret world in the gaps between brain cells, Physics Today, 75 (2022) 26-32. https://doi.org/10.1063/PT.3.4999
C. Nicholson, Brain interstitial structure revealed through diffusive spread of molecules, in: A. Bunde, J. Caro, C. Chmelik, J. Kärger, G. Vogl (Eds.) Diffusive Spreading in Nature, Technology and Society, Springer, 2023, pp. 97-120. https://doi.org/10.1007/978-3-031-05946-9_6
J. Tønnesen, S. Hrabĕtová, F.N. Soria, Local diffusion in the extracellular space of the brain, Neurobiology of Disease, 177 (2023) 105981. https://doi.org/10.1016/j.nbd.2022.105981
C. Nicholson, Diffusion and related transport properties in brain tissue, Reports on Progress in Physics, 64 (2001) 815-884. https://doi.org/10.1088/0034-4885/64/7/202
J. Odackal, R. Colbourn, N.J. Odackal, L. Tao, C. Nicholson, S. Hrabĕtová, Real-time iontophoresis with tetramethyl-ammonium to quantify volume fraction and tortuosity of brain extracellular space, Journal of Visualized Experiments (JoVE), (2017) e55755. https://doi.org/10.3791/55755
E. Syková, C. Nicholson, Diffusion in brain extracellular space, Physiological Reviews, 88 (2008) 1277-1340. https://doi.org/10.1152/physrev.00027.2007
L. Tao, C. Nicholson, Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells, Journal of Theoretical Biology, 229 (2004) 59-68. https://doi.org/10.1016/j.jtbi.2004.03.003
C. Nicholson, P. Kamali-Zare, Reduction of dimensionality in Monte Carlo simulation of diffusion in extracellular space surrounding cubic cells, Neurochemical Research 45 (2020) 42-52. https://doi.org/10.1007/s11064-019-02793-6
C. Nicholson, Sheet and void porous media models for brain interstitial space, Journal of the Royal Society Interface, 20 (2023) 20230223. https://doi.org/10.1098/rsif.2023.0223
J.R. Stiles, T.M. Bartol, Monte Carlo methods for simulating realistic synaptic microphysiology using MCell, in: E. De Schutter (Ed.) Computational Neuroscience: Realistic Modeling for Experimentalists, CRC Press, London, 2001, pp. 87-127.
www.mcell.org.
L. Xie, H. Kang, Q. Xu, M.J. Chen, Y. Liao, M. Thiyagarajan, J. O'Donnell, D.J. Christensen, C. Nicholson, J.J. Iliff, T. Takano, R. Deane, M. Nedergaard, Sleep drives metabolite clearance from the adult brain, Science, 342 (2013) 373-377. https://doi.org/10.1126/science.1241224
T. Bohr, P.G. Hjorth, S.C. Holst, S. Hrabĕtová, V. Kiviniemi, T. Lilius, I. Lundgaard, K.A. Mardal, E.A. Martens, Y. Mori, U.V. Nägerl, C. Nicholson, A. Tannenbaum, J.H. Thomas, J. Tithof, H. Benveniste, J.J. Iliff, D.H. Kelley, M. Nedergaard, The glymphatic system: Current understanding and modeling, iScience, 25 (2022) 104987. https://doi.org/10.1016/j.isci.2022.104987
R. Colbourn, J. Hrabe, C. Nicholson, M. Perkins, J.H. Goodman, S. Hrabĕtová, Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter, Journal of Physiology, 599 (2021) 3195-3220. https://doi.org/10.1113/JP281544
R.G. Thorne, C. Nicholson, In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space, Proceedings of the National Academy of Sciences USA, 103 (2006) 5567-5572. https://doi.org/10.1073/pnas.0509425103
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