The Effect of Dead-Space Microdomain Entrance Size and Volume on Brain Extracellular Space Diffusion

Authors

  • Emma Xiao State University of New York Downstate Health Sciences University, Brooklyn, NY, USA. Staten Island Technical High School, Staten Island, NY, USA
  • Sabina Hrabetova State University of New York Downstate Health Sciences University, Brooklyn, NY, US
  • Jan Hrabe State University of New York Downstate Health Sciences University, Brooklyn, NY, USA. Nathan Kline Institute, Orangeburg, NY, USA

DOI:

https://doi.org/10.62721/diffusion-fundamentals.39.1266

Keywords:

Diffusion

References

E. Syková, C. Nicholson, Diffusion in brain extracellular space, Physiol. Rev. 88 (2017) 1277-1340. https://doi.org/10.1152/physrev.00027.2007

J. Hrabe, S. Hrabetova, K. Segeth, A model of effective diffusion and tortuosity in the extracellular space of the brain, Biophys. J. 87 (2004) 1606-1617. https://doi.org/10.1529/biophysj.103.039495

S. Hrabetova, C. Nicholson, Contribution of dead-space microdomains to tortuosity of brain extracellular space, Neurochem. Int. 45 (2004) 467-477. https://doi.org/10.1016/j.neuint.2003.11.011

L. Tao, C. Nicholson, Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells, J. Theor. Biol. 229 (2004) 59-68. https://doi.org/10.1016/j.jtbi.2004.03.003

N. Korogod, C.C. Petersen, G.W. Knott, Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation, eLife 4 (2015) e05793. https://doi.org/10.7554/eLife.05793

C. Nicholson, Sheet and void porous media models for brain interstitial space, J. R. Soc. Interface. 20 (2023) 20230223. https://doi.org/10.1098/rsif.2023.0223

J. R. Stiles, T. M. Bartol, Monte Carlo methods for simulating realistic synaptic microphysiology using MCell, in: E. De Schutter (Ed.), Computational Neuroscience: Realistic Modeling for Experimentalists, CRC Press, Boca Raton, 2001, pp. 87-127.

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Published

2025-11-03

How to Cite

[1]
E. Xiao, S. Hrabetova, and J. Hrabe, “The Effect of Dead-Space Microdomain Entrance Size and Volume on Brain Extracellular Space Diffusion”, diffus. fundam., vol. 39, Nov. 2025, doi: 10.62721/diffusion-fundamentals.39.1266.